A thermosensitive chitosan hydrogel enabled MnO ₂ nanozyme delivery with NO release for enhanced corneal repair

Peifang Xu; Yiming Sun; Jun Huang; Yishu Zhang; Tong Zhou; J Wang; Pengjie Chen; Mingyu Xu; Yifan Zhou; Sui Yu; Juan Ye

doi:10.1039/d5tb02635k

January 1, 2026Journal of Materials Chemistry B

A thermosensitive chitosan hydrogel enabled MnO ₂ nanozyme delivery with NO release for enhanced corneal repair

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Key Points

To investigate the effects of a thermosensitive hydrogel with MnO2 nanozyme on corneal repair.
Developed a thermosensitive chitosan hydrogel containing MnO2 nanozymes.
Evaluated effects on corneal re-epithelialization in vitro and in vivo.
Measured levels of reactive oxygen species and inflammation markers.
Significantly enhanced corneal re-epithelialization observed in treated models.
Decreased levels of reactive oxygen species due to MnO2 activity.
Suppressed inflammation and improved macrophage polarization metrics.

Implication

A thermosensitive hydrogel enhances corneal repair by promoting healing and reducing inflammation.

Abstract

The thermosensitive HBC_Arg/MnO 2 hydrogel promotes rapid corneal re-epithelialization by scavenging ROS, suppressing inflammation, and modulating macrophage polarization, thereby restoring transparency and inhibiting neovascularization.

Discussion

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6969d44b940543b9777092c2 https://doi.org/10.1039/d5tb02635k

View at Publisher

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A thermosensitive chitosan hydrogel enabled MnO ₂ nanozyme delivery with NO release for enhanced corneal repair

Key Points

Implication

Abstract

Discussion

Cite This Study

A thermosensitive chitosan hydrogel enabled MnO ₂ nanozyme delivery with NO release for enhanced corneal repair

Key Points

Implication

Abstract

Discussion

Cite This Study

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