A thermosensitive chitosan hydrogel enabled MnO 2 nanozyme delivery with NO release for enhanced corneal repair

Key Points

• To investigate the effects of a thermosensitive hydrogel with MnO2 nanozyme on corneal repair.
• Developed a thermosensitive chitosan hydrogel containing MnO2 nanozymes.
• Evaluated effects on corneal re-epithelialization in vitro and in vivo.
• Measured levels of reactive oxygen species and inflammation markers.
• Significantly enhanced corneal re-epithelialization observed in treated models.
• Decreased levels of reactive oxygen species due to MnO2 activity.
• Suppressed inflammation and improved macrophage polarization metrics.