What question did this study set out to answer?

This research aims to develop a palladium-catalyzed method for alkenylation using carboxylic acids.

January 16, 2026

Palladium‐Catalyzed Decarboxylative C─H Alkenylation of Proaromatic Acids With Allyl Alcohols and N ‐Allyl Sulfonamides

YLYin‐Chia LuNational University of Kaohsiung VKVeerabhushanam KadiyalaNational University of Kaohsiung PMPrahallad MeherIndian Institute of Technology Jodhpur

Key Points

This research aims to develop a palladium-catalyzed method for alkenylation using carboxylic acids.
Utilized palladium as a catalyst for the reaction.
Examined the decarboxylative C─H alkenylation with allylic alcohols and N-allyl sulfonamides.
Conducted mechanistic studies to understand reaction pathways.
Tested the method under mild and operationally simple conditions.
Successfully accessed a range of vinylarenes with diverse substituents.
The reaction demonstrated good regioselectivity.
Mechanistic studies confirmed the involvement of carboxylate-directed activation.
The method is scalable for practical applications.

Abstract

ABSTRACT We develop an efficient palladium‐catalyzed decarboxylative C─H alkenylation of cyclohexa‐2,5‐dienyl carboxylic acids with allylic alcohols and N ‐allyl sulfonamides, enabling regioselective access to diverse vinylarenes. The transformation proceeds under mild, operationally simple conditions and tolerates a broad range of alkyl, aryl, and heteroaryl substituents. Mechanistic studies reveal that the reaction is going via carboxylate‐directed C─H activation and olefin insertion step. The method is scalable and offers a practical route to vinylarene scaffold‐containing biologically relevant moieties.

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