Design, synthesis, and biological evaluation of novel chalcone derivatives: integrating molecular docking with in vivo anti-inflammatory and antinociceptive studies

Key Points

• The study aims to design and evaluate novel chalcone derivatives for their anti-inflammatory and pain-relieving properties.
• Synthesize various chalcone derivatives.
• Conduct molecular docking studies to predict interactions with targets.
• Perform in vivo anti-inflammatory and antinociceptive evaluations.
• Certain chalcone derivatives significantly reduced inflammation in animal models.
• Positive outcomes in pain relief were observed with specific compounds.
• The docking studies correlated well with biological activities.