Establishment and Optimization of a Patient-Reported Outcome–Based Electronic-Diary for Symptoms Evaluation in Patients With Gastroesophageal Reflux Disorder: Prospective Cohort Study

Yun-Chun Chen; Yen-Po Wang; Jui-Hsuan Hung; Dawei Wang; Shang-Liang Wu; Li-Fen Chen; Yueh-Hsin Ping; Mei-Lien Pan; Ching-Liang Lu

doi:10.2196/83680

January 1, 2026

Establishment and Optimization of a Patient-Reported Outcome–Based Electronic-Diary for Symptoms Evaluation in Patients With Gastroesophageal Reflux Disorder: Prospective Cohort Study

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Key Points

This study aimed to develop a patient-reported outcome e-diary for tracking GERD symptoms and analyze the impact of symptom frequency on adherence.
Developed a PRO-based electronic diary for GERD monitoring over 8 weeks
Analyzed adherence rates across three optimization stages
Calculated weekly symptom frequency by summing symptomatic days
Employed multiple regression analyses to assess adherence effects
Initial adherence was 47.2% for nighttime, 40% for daytime, and 57.6% overall symptoms
Optimization improved nighttime adherence by 12.5% and daytime by 21.7% after implementing SMS reminders
Symptom frequency positively associated with adherence, increasing by 0.7% overall and 0.9% for both daytime and nighttime symptoms per symptom increase
Engagement declined over the study period, with nighttime adherence dropping from 80.1% to 61.5%

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Implication

Prospective cohort study demonstrates that SMS reminders improve adherence in patients with GERD symptoms, indicating more effective symptom tracking.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6969d518940543b97770a14f https://doi.org/10.2196/83680

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Establishment and Optimization of a Patient-Reported Outcome–Based Electronic-Diary for Symptoms Evaluation in Patients With Gastroesophageal Reflux Disorder: Prospective Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Establishment and Optimization of a Patient-Reported Outcome–Based Electronic-Diary for Symptoms Evaluation in Patients With Gastroesophageal Reflux Disorder: Prospective Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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