Nanomedical approaches to deplete intracellular glutathione in oncology

Javier Bonet-Aleta; José L. Hueso; Andrea Mosseri; Jesús Santamaría

doi:10.1039/d5sc09556e

January 1, 2026Chemical ScienceOpen Access

Nanomedical approaches to deplete intracellular glutathione in oncology

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Key Points

The focus is on exploring nanomedical methods to lower intracellular glutathione levels in cancer cells to enhance treatment efficacy.
Developed nanomedical approaches targeting glutathione depletion
Analyzed the impact of glutathione levels on chemoresistance in cancer cells
Utilized various therapeutic intervention strategies
Demonstrated that reducing glutathione enhances sensitivity to chemotherapy
Observed a significant correlation between glutathione levels and chemoresistance in various cancer types

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Implication

This intervention aims to reduce chemoresistance in cancer cells by depleting glutathione, indicating promising clinical applications.

Abstract

Glutathione (GSH) plays a critical role in maintaining redox homeostasis and conferring chemoresistance to cancer cells, making it an attractive target for therapeutic intervention.

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Cite This Study

Bonet-Aleta et al. (2026) studied this question.

synapsesocial.com/papers/696b25a9d2a12237a9349063 https://doi.org/10.1039/d5sc09556e

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Nanomedical approaches to deplete intracellular glutathione in oncology

Key Points

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Implication

Abstract

Discussion

Cite This Study

Nanomedical approaches to deplete intracellular glutathione in oncology

Key Points

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Implication

Abstract

Discussion

Cite This Study

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