Key result
Higher serum uric acid linked to ~32% greater risk of persistent AF per SD.
Why the study?
The study investigated the association between serum uric acid levels and atrial fibrillation burden in Chinese patients with AF.
Are higher serum uric acid levels associated with increased atrial fibrillation burden in patients with AF?
Are higher serum uric acid levels associated with increased atrial fibrillation burden in patients with AF?
Elevated serum uric acid levels are positively associated with a higher atrial fibrillation burden and an increased risk of persistent AF in a dose-dependent manner.
Higher UA linked to persistent AF risk; hypothesis-generating association requiring prospective trials before any clinical consideration.
Objective: This study investigated the association between serum uric acid (UA) levels and atrial fibrillation (AF) burden in Chinese patients with AF. Methods: In this cross-sectional study, AF burden was defined as the proportion of AF duration to total monitoring time, recorded by a patch device over ≥24 hours. Serum UA levels were measured at the start of monitoring. Multivariate logistic regression was used to assess associations. Results: A total of 952 patients with AF (66.4% women; median age 64 years) were included. A 1-SD increase in UA (91.4 μmol/L) was associated with elevated risk of persistent AF (adjusted OR: 1.32; 95% CI: 1.12–1.55; P < 0.001). The highest UA quintile had a greater risk of persistent AF than the lowest quintile of patients (adjusted OR: 2.43; 95% CI: 1.49–3.98; P for trend < 0.001). Conclusion: Serum UA levels are positively associated with AF burden in a dose-dependent manner. UA might serve as an accessible biomarker and potential therapeutic target for AF burden assessment.
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Kong et al. (2026) studied this question. A 1-SD increase in serum uric acid (91.4 μmol/L) was associated with a 32% elevated risk of persistent atrial fibrillation (adjusted OR: 1.32).
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