Design, synthesis, in silico studies, and antiproliferative activity of a novel series of thiazole/1,2,3-triazole hybrids as apoptosis inducers and multi-kinase inhibitors endowed with anti-breast cancer activity

Key Points

• The study aims to develop thiazole/1,2,3-triazole hybrids with anticancer properties.
• Design and synthesize thiazole/triazole hybrids
• Conduct in vitro studies to assess anticancer efficacy
• Evaluate compounds against MCF-7 breast cancer cells
• Compounds 10c, 10e, 10k, 10m, 10n, and 10o showed superior anticancer activity
• Particularly effective against MCF-7 breast cancer cells