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January 17, 2026npj Parkinson s DiseaseOpen Access

Early retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson’s disease model

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Authors

CMChae-Eun MoonSLSeung‐Jae LeeHSHaesol Shin

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Overview

Transgenic mice exhibit retinal dysfunction and molecular changes, indicating early neurodegeneration in Parkinson’s disease.

Key Points

  • Investigate retinal changes and their molecular basis in a model of Parkinson’s disease.
  • Utilized a transgenic mouse model overexpressing A53T-mutant human α-synuclein
  • Assessed retinal function with electroretinography
  • Examined retinal structure via optical coherence tomography
  • Conducted proteomic profiling to analyze molecular alterations
  • Detected early retinal dysfunction marked by reduced oscillatory potential amplitudes
  • Observed thickness changes in retinal layers, including thinning of the nerve fiber layer
  • Identified increased α-synuclein accumulation and altered protein levels linked to inflammation
  • Highlighted retinal changes as early indicators of neurodegeneration in Parkinson’s disease

Cite This Study

Moon et al. (2026) studied this question.

synapsesocial.com/papers/696b2696d2a12237a9349dc4https://doi.org/10.1038/s41531-026-01261-7
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