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January 17, 2026Lipids in Health and Disease1 citationsOpen Access

Association of apolipoprotein B and excess apolipoprotein B with cardiovascular risk in type 2 diabetes: a prospective cohort study of the UK Biobank

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LLLijuan LyuQilu Hospital of Shandong UniversityCKChunyu KaoShandong Center for Disease Control and PreventionJSJin SuShandong University

Key Points

  • The research aims to explore the relationship between apolipoprotein B levels and cardiovascular risk in individuals with type 2 diabetes.
  • Prospective cohort study design utilizing UK Biobank data.
  • Assessment of apolipoprotein B levels in participants with type 2 diabetes.
  • Evaluation of cardiovascular outcomes related to apolipoprotein B and excess apolipoprotein B.
  • Apolipoprotein B is independently linked to atherosclerotic cardiovascular disease risk in type 2 diabetes.
  • Excess apolipoprotein B showed enhanced risk discrimination compared to conventional lipid measures.
  • Clinical applicability of excess apolipoprotein B needs further validation and standardization for practical use.

Abstract

In T2DM, apoB is independently associated with ASCVD but adds limited discrimination over conventional lipids. Excess apoB yielded improved discrimination and reclassification, and may serve as a complementary ASCVD risk marker, particularly in statin-treated settings. However, its clinical application requires external validation and standardization.

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Cite This Study

Lyu et al. (2026) studied this question.

synapsesocial.com/papers/696b2696d2a12237a9349ddbhttps://doi.org/10.1186/s12944-025-02852-8
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