Excessive Short-acting Beta-agonists Prescriptions in COPD Treated with Triple Inhaler Therapy: A Possible Marker of Frequent Exacerbations. A Retrospective Cohort Study

Bruno Sposato; Leonardo Gianluca Lacerenza; E. Petrucci; Alberto Ricci; Alberto Cresti; P. Baratta; Andrea Serafini; Claudio Micheletto; Maurizio Di Tomassi; Antonio Perrella; Valerio Alonzi; Sara Croce; Marco Scalese

doi:10.4274/thoracrespract.2025.2025-6-1

January 15, 2026Thoracic research and practiceOpen Access

Excessive Short-acting Beta-agonists Prescriptions in COPD Treated with Triple Inhaler Therapy: A Possible Marker of Frequent Exacerbations. A Retrospective Cohort Study

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Key Points

This study aims to investigate the link between short-acting beta-agonist prescriptions and exacerbation rates in COPD patients on triple inhaler therapy.
Retrospective cohort design
Analysis of SABA prescriptions alongside exacerbation rates
Assessment via antibiotic prescription records
SABA prescriptions were frequently observed despite triple inhaler therapy
A positive correlation was found between SABA use and increased number of exacerbations
Excessive SABA prescriptions suggest inadequate control of COPD symptoms

Implication

Retrospective cohort study reveals that SABA prescriptions correlate with frequent exacerbations in COPD, suggesting an area for clinical focus.

Abstract

A significant number of subjects were prescribed SABA despite SITT therapy. A relationship between SABA packages and the number of exacerbations, assessed by OC/antibiotic prescriptions, was observed. Excessive SABA use or prescription may indicate frequent exacerbations in patients with COPD despite receiving maximal inhaled therapy.

Discussion

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Cite This Study

Sposato et al. (2026) studied this question.

synapsesocial.com/papers/696b26b2d2a12237a9349f81 https://doi.org/10.4274/thoracrespract.2025.2025-6-1

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Excessive Short-acting Beta-agonists Prescriptions in COPD Treated with Triple Inhaler Therapy: A Possible Marker of Frequent Exacerbations. A Retrospective Cohort Study

Key Points

Implication

Abstract

Discussion

Cite This Study

Excessive Short-acting Beta-agonists Prescriptions in COPD Treated with Triple Inhaler Therapy: A Possible Marker of Frequent Exacerbations. A Retrospective Cohort Study

Key Points

Implication

Abstract

Discussion

Cite This Study

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