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To synthesize and characterize PVP microparticles containing L-serine and analyze their release kinetics.

Synthesis Characterization and In Vitro Release Kinetics of L‐Serine From PVP Microparticles

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To synthesize and characterize PVP microparticles containing L-serine and analyze their release kinetics.
Synthesis of L-serine-loaded PVP microparticles
Characterization using FTIR, XRD, and EDS SEM
Release kinetics modeling using zero-order, Higuchi, and Korsmeyer-Peppas models
Calculation of kinetic constants for each model
L-serine release from microparticles shows 65% within 120 min
Release kinetics follows zero-order and Korsmeyer-Peppas model
Korsmeyer-Peppas model shows n value of 0.9 indicating super-case II transport
The zero-order rate constant was found to be 0.305 mg/min, matching graphical values of 0.311 mg/min.

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Demonstrates the release kinetics of L-serine in PVP microparticles, suggesting applications in sustained release formulations.

Ranu Chaturvedi (2026) studied this question.

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