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To explore how METTL3 influences Leydig cell proliferation through miR-145 and PCK1 in goats.

METTL3 regulates Leydig cell proliferation via miR-145-PCK1 mediated gluconeogenesis in goats

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To explore how METTL3 influences Leydig cell proliferation through miR-145 and PCK1 in goats.
Analyzed METTL3 expression in goat Leydig cells during testicular development.
Assessed the impact of METTL3 on miR-145-3p and PCK1 levels.
Evaluated cell proliferation and metabolic changes in Leydig cells.
METTL3 levels decreased in Leydig cells during testicular development.
Lower METTL3 reduced mature miR-145-3p, increasing PCK1 expression.
Enhanced PCK1 activated gluconeogenesis, raising glucose and mitochondrial potential, leading to increased cell proliferation.

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Investigation reveals the METTL3/miR-145-3p/PCK1 pathway promotes Leydig cell proliferation, indicating epigenetic links to male reproductive health.

Tang et al. (2026) studied this question.

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Investigation reveals the METTL3/miR-145-3p/PCK1 pathway promotes Leydig cell proliferation, indicating epigenetic links to male reproductive health.