What question did this study set out to answer?

The study aims to identify distinct clinicopathologic features and immunohistochemical markers for enfortumab vedotin-induced cutaneous toxicity.

January 18, 2026International Journal of Dermatology

Clinicopathologic and Immunohistochemical Features of Enfortumab Vedotin‐Induced Cutaneous Toxicity

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Authors

FRFederico RepettoBrigham and Women's Hospital SJSoma JobbagyBrigham and Women's Hospital ELE. LeeTufts University

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Implication

This retrospective case series defines features of cutaneous toxicity in patients treated with enfortumab vedotin, suggesting a framework for identification.

Key Points

The study aims to identify distinct clinicopathologic features and immunohistochemical markers for enfortumab vedotin-induced cutaneous toxicity.
Retrospective case series of nineteen patients receiving enfortumab vedotin and ten controls with similar dermatoses.
Assessment of histologic patterns and immunohistochemical markers for comparison.
Blinded review to evaluate immunoglobulin G (IgG), Nectin-4, and cytotoxic T-cells.
All enfortumab vedotin cases showed distinct patterns of interface dermatitis.
Epidermal 'ring' mitoses were frequently observed in EV cases but absent in controls.
Intercellular IgG staining was noted in 83% of EV cases versus 20% in controls, indicating high sensitivity and specificity for diagnosis.

Cite This Study

Repetto et al. (2026) studied this question.

synapsesocial.com/papers/696c7835eb60fb80d1396688 https://doi.org/10.1111/ijd.70258

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Implication

This retrospective case series defines features of cutaneous toxicity in patients treated with enfortumab vedotin, suggesting a framework for identification.

Clinicopathologic and Immunohistochemical Features of Enfortumab Vedotin‐Induced Cutaneous Toxicity

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinicopathologic and Immunohistochemical Features of Enfortumab Vedotin‐Induced Cutaneous Toxicity

Discussion

Member takes

Implication

Key Points

Cite This Study

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