Smart Eutectic Gallium–Indium: “All-in-One” Nanoplatform for Computed Tomography Imaging-Guided Near Infrared-II Photothermal Therapy

Liquid metal is considered an intelligent material capable of responding to environmental changes, and its applications in the biomedical field have been widely explored. In this work, we have developed a gallium-indium alloy nanomaterial (EGaIn-PEG NPs) as an intelligent platform for precise tumor photothermal therapy. Our research demonstrates that EGaIn-PEG NPs exhibit excellent computed tomography (CT) imaging contrast performance. Furthermore, under 1064 nm laser irradiation, EGaIn-PEG NPs show efficient heating effects, high photothermal conversion efficiency, and stability, enabling CT-guided tumor NIR-II photothermal therapy. This work promises to offer insights into the application of liquid metals for NIR-II tumor photothermal therapy.