Comparative observational study evaluates uterine artery Doppler metrics in women with unexplained infertility, suggesting impaired blood flow may affect fertility.
Background: Unexplained infertility remains a diagnostic challenge, with impaired uterine perfusion and suboptimal endometrial receptivity hypothesized as potential contributing factors. This study aimed to compare mid-luteal phase uterine artery Doppler parameters between infertile and fertile women. Methods: A prospective, comparative observational study was conducted on 60 women attending the Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur. Group I included 30 women with unexplained infertility, while Group II comprised 30 age-matched fertile controls. All participants underwent mid-luteal phase transvaginal sonography to assess uterine artery Doppler indices—Pulsatility Index (PI), Resistive Index (RI), Peak Systolic Velocity (PSV), and End-Diastolic Velocity (EDV). Data were analysed using SPSS version 29.0. Results: Infertile women demonstrated significantly elevated PI (3.03 ± 0.88 vs. 1.91 ± 0.54; p = 0.01) and RI (0.93 ± 0.40 vs. 0.81 ± 0.35; p = 0.01), along with a significant reduction in EDV (8.47 ± 2.25 cm/s vs. 12.20 ± 1.77 cm/s; p = 0.01), indicating compromised uterine perfusion. Conclusion: Women with unexplained infertility exhibit impaired uterine artery blood flow. Uterine artery Doppler serve as valuable non-invasive tools for evaluating endometrial receptivity and guiding infertility management.
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International Journal of Medical Science and Advanced Clinical Research (IJMACR) (2025) studied this question.
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