Digested Metallic NMs on the tri-culture intestinal barrier model -deliverable 1.17- EU project NanoHarmony (Grant agreement No 885931) Raw data for Annex 6.4 OECD Guidance Document for in vitro testing of the intestinal fate of ingested nanomaterials

This document reports the raw data generated within the EU H2020 NanoHarmony project (Grant Agreement, GA) relating to uptake and translocation experiments of digested nanomaterials (NMs) using a simulated digestion of metal oxides (namely ZnO, TiO₂ and SiO₂) in an in vitro model of intestinal barrier.With regard to the barrier model, a tri-culture system consisting of Caco-2/HT29 and Raji B cells was used. The document also includes data on the effects of the digests NMs on Caco-2 monocultures, as well as their cytotoxicity data.The experiments were conducted in two different laboratories: the Italian Institute of Health (Istituto Superiore di Sanità, ISS)