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This research examines the cancer risk and mortality rates following Kaposi sarcoma in individuals living with HIV.

January 20, 2026Cancer Causes & Control0 citationsOpen Access

Cancer Risk and Mortality Following Kaposi Sarcoma Among People with HIV in the United States, 2000 to 2019

SPSally PeprahNational Cancer Institute EEEA EngelsNational Institutes of Health QLQianlai Luo

Key Points

This research examines the cancer risk and mortality rates following Kaposi sarcoma in individuals living with HIV.
Examined data from the HIV/AIDS Cancer Match Study.
Included 2,645 people with HIV and Kaposi sarcoma in the analysis.
Compared subsequent cancer risks between those with and without Kaposi sarcoma.
Subsequent cancer risk was 2.8 times higher for those with Kaposi sarcoma compared to those without.
Mortality rates after Kaposi sarcoma showed a significant decline from 2000 to 2002 and from 2012 to 2015 (hazard ratio = 0.64).

Abstract

Abstract People with HIV (PWH) have increased Kaposi sarcoma (KS) risk. Among 2,645 PWH with KS in the United States HIV/AIDS Cancer Match Study, subsequent cancer risk was elevated 2.8-fold (95% confidence interval CI: 2.4–3.3) compared to PWH without KS. Mortality after KS declined 2000–2002 and 2012–2015 (hazard ratio = 0.64; 95%CI: 0.55–0.74).

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