What question did this study set out to answer?

To examine how vulnerability influences outcomes for locally advanced non-small cell lung cancer patients receiving concurrent chemoradiotherapy.

January 20, 2026Therapeutic Advances in Medical OncologyOpen Access

Impact of vulnerability on concurrent chemoradiotherapy outcomes in patients with locally advanced non-small cell lung cancer using an integrated clinical trial database

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Authors

KMKenji MorimotoKyoto Prefectural University of Medicine TYT. YamadaKyoto Prefectural University of Medicine NNNaoya NishiokaKyoto Prefectural University of Medicine

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Implication

Analysis reveals vulnerability affects overall survival in lung cancer patients undergoing chemoradiotherapy, suggesting tailored strategies are needed.

Key Points

To examine how vulnerability influences outcomes for locally advanced non-small cell lung cancer patients receiving concurrent chemoradiotherapy.
Analyzed data from the Japan Lung Cancer Society Integrated Clinical Trial Database with 1288 patients.
Defined vulnerability based on age, chronic obstructive pulmonary disease, chronic kidney disease, or cancer cachexia.
Assessed overall survival and progression-free survival among vulnerable and non-vulnerable groups.
Vulnerable patients had significantly shorter overall survival (19.7 vs 27.4 months, p = 0.003).
Progression-free survival did not differ significantly between groups (8.8 vs 10.4 months, p = 0.151).
Cachexia was strongly associated with shorter overall and progression-free survival.

Cite This Study

Morimoto et al. (2026) studied this question.

synapsesocial.com/papers/696f1a239e64f732b51ee768 https://doi.org/10.1177/17588359251414535

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Implication

Analysis reveals vulnerability affects overall survival in lung cancer patients undergoing chemoradiotherapy, suggesting tailored strategies are needed.

Impact of vulnerability on concurrent chemoradiotherapy outcomes in patients with locally advanced non-small cell lung cancer using an integrated clinical trial database

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of vulnerability on concurrent chemoradiotherapy outcomes in patients with locally advanced non-small cell lung cancer using an integrated clinical trial database

Discussion

Member takes

Implication

Key Points

Cite This Study

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