We introduce a replicate aware framework for evaluating global structural coherence in ensembles of candidate structures. The framework is designed to operate independently of how candidate structures are generated and applies uniformly across experimental, simulated, heuristic, or predictive settings. The central contribution is a coherence functional defined on pairwise structural disagreement matrices that detects regime level coordination and fragmentation without assuming monotonic degradation, smooth transitions, uniform sampling, or a specific generative model. The framework explicitly preserves replicate identity, accommodates uneven or constrained ensemble generation, and provides structural guarantees through formal bounds and stability properties. This work establishes a generator agnostic, post-hoc evaluation layer intended for reuse, extension, and integration across scientific and commercial contexts.
Allen Allen (Sun,) studied this question.