What question did this study set out to answer?

To evaluate treatment modalities and recurrence rates of lentigo maligna in a nationwide cohort.

January 20, 20262 citations

A nationwide study of treatment and recurrence rate of lentigo maligna in the Netherlands.

JZJudith Zoutendijk LHLoes M. Hollestein AMAntien L Mooyaart

Key Points

To evaluate treatment modalities and recurrence rates of lentigo maligna in a nationwide cohort.
Utilized a nationwide database to analyze treatment approaches for lentigo maligna cases.
Assessed histological outcomes post-surgery, specifically rates of upstaging to lentigo maligna melanoma.
Examined recurrence outcomes associated with non-surgical treatment modalities.
14% of histologically proven lentigo maligna cases were upstaged to lentigo maligna melanoma after surgery.
Significant recurrences were noted among patients treated with non-surgical options.
The findings highlight the need to balance treatment efficacy and potential side effects, especially in delicate areas like the head and neck.

Abstract

The most applied diagnostic modality in LM patients in the Netherlands is punch biopsy, and most LM patients are treated with wide local excision in line with the Dutch melanoma guidelines. In this nationwide database, 14% of the histologically proven LM cases were upstaged to LMM after surgery. This should be taken into account when choosing treatment modalities, especially when considering non-surgical treatment modalities. The significant number of recurrences among non-surgical therapies demonstrates the complexity of treating LM and the importance of balance between histological clearance and sometimes mutilating surgery in the head and neck region.

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