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January 17, 2026BMC AnesthesiologyOpen Access

Low dose of sugammadex versus neostigmine for reversal of rocuronium induced moderate neuromuscular block: a randomized controlled trial

Sonia Hadj-Mimoune Louis Morisson Sami Ellassraoui Moulay Idrissi Marceline Quach Nadia Godin Walid Oulehri Louis-Philippe Fortier Olivier Verdonck Pascal Laferrière-Langlois P. Richebé

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Key Points

The study aims to compare the effectiveness of low doses of sugammadex versus neostigmine in reversing moderate neuromuscular blocks induced by rocuronium.
Randomized controlled trial design
Participants received low doses of either sugammadex or neostigmine
Assessment of neuromuscular block reversal effectiveness
Sugammadex showed a faster reversal time compared to neostigmine
Both drugs were effective in reversing the neuromuscular block
No significant side effects were reported for either drug

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Implication

This randomized controlled trial compares reversal of neuromuscular block using sugammadex and neostigmine.

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Cite This Study

Hadj-Mimoune et al. (2026) studied this question.

synapsesocial.com/papers/696f1a629e64f732b51ee9f1 https://doi.org/10.1186/s12871-025-03581-2

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patientsOriginal Research · 2013 · 49 citations
2Comparison of sugammadex and pyridostigmine bromide for reversal of rocuronium-induced neuromuscular blockade in short-term pediatric surgery: a prospective randomized studyRCT · 2019 · 10 citations
3Neostigmine Versus Sugammadex for Reversal of Neuromuscular Blockade in Elderly Patients: A Blinded Randomised Study2025 · 1 citations
4Comparison of reversal with neostigmine of low‐dose rocuronium vs. reversal with sugammadex of high‐dose rocuronium for a short procedureRCT · 2017 · 31 citations
5Half-dose sugammadex with neostigmine versus full-dose sugammadex for reversal of rocuronium in laparoscopic bariatric surgeryRCT · 2020 · 1 citations

Sugammadex versus neostigmine for reversal of neuromuscular blockade and postoperative pulmonary complications (SNaPP): an international, randomised, controlled, phase 4 trial2026
Rocuronium Reversal in the Emergency Department: Retrospective Evaluation of Hemodynamic Instability Following Administration of Sugammadex Versus Neostigmine With Glycopyrrolate2021
Association of neuromuscular reversal by sugammadex and neostigmine with 90-day mortality after non-cardiac surgery2020
Efficacy and safety of perioperative intravenous esketamine for the prevention of postoperative sleep disturbance and reduction of its incidence in adult surgical patients: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials (RCTs)BMC Anesthesiology · 2026
Assessing acceptability, feasibility, and utilization in a peer-to-peer tele-critical care model: a mixed-methods analysis to inform scalable remote ICU modelsBMC Anesthesiology · 2026

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