This study aims to explore how CNOT3 influences ovarian aging by affecting oocyte maturation and embryonic stem cell differentiation.
Investigated the role of CNOT3 in ovarian aging mechanisms.
Assessed the effects of CNOT3 on oocyte maturation rates.
Examined the differentiation of embryonic stem cells in the context of ovarian aging.
CNOT3 was found to significantly enhance oocyte maturation.
The therapeutic effects of embryonic stem cells were improved with CNOT3 intervention.
Abstract
Overall, our results indicated that CNOT3 counteracted OA and enhanced the therapeutic benefit of ESCs on OA. These findings will provide useful information for the improvement of therapeutic methods of OA.