The Entropic Vise: A Physics-Based Framework for High-Barrier Thermodynamic Targeting of HIV-1 Through Constrained Generative Modeling and Real-Time Latency Detection

Rhine Lesther Tague

doi:10.5281/zenodo.18287138

January 18, 2026Open Access

The Entropic Vise: A Physics-Based Framework for High-Barrier Thermodynamic Targeting of HIV-1 Through Constrained Generative Modeling and Real-Time Latency Detection

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Key Points

This research aims to develop a physics-based framework for addressing high-barrier thermodynamic challenges in HIV-1 targeting.
Revised hypothesis focusing on high fitness cost barriers related to Enfuvirtide resistance.
Incorporated findings from an adversarial audit by K-Dense AI to strengthen the model.
Introduced a Limitations section to discuss potential constraints in the framework.
Identified the importance of fitness cost barriers in HIV-1 resistance to Enfuvirtide.
Suggested the need for Deep Mutational Scanning to validate findings and improve targeting efficiency.

Implication

This framework targets HIV-1 using thermodynamic principles, suggesting novel implications for treatment strategies.

Abstract

Version 2.2 Update: This revision incorporates findings from an adversarial audit by K-Dense AI. The hypothesis has been refined from "thermodynamic impossibility" to "high fitness cost barriers" to align with clinical data on Enfuvirtide resistance. Features a new "Limitations" section and calls for Deep Mutational Scanning validation.

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Cite This Study

Rhine Lesther Tague (2026) studied this question.

synapsesocial.com/papers/696f1a629e64f732b51eeb73 https://doi.org/10.5281/zenodo.18287138

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The Entropic Vise: A Physics-Based Framework for High-Barrier Thermodynamic Targeting of HIV-1 Through Constrained Generative Modeling and Real-Time Latency Detection

Key Points

Implication

Abstract

Discussion

Cite This Study

The Entropic Vise: A Physics-Based Framework for High-Barrier Thermodynamic Targeting of HIV-1 Through Constrained Generative Modeling and Real-Time Latency Detection

Key Points

Implication

Abstract

Discussion

Cite This Study

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