Key result
Elevated Metabolic Score for Visceral Fat linked to ~62% higher incident CVD risk.
Cohort (n=3,815)
Yes
Longitudinal study finds METS-VF profiles predict cardiovascular disease in CKM syndrome adults, suggesting targeted interventions may reduce risk.
METS-VF profiles are independently associated with incident CVD in CKM syndrome stages 0-3, more strongly in late stages. eGDR significantly mediates this relationship, supporting the "obesity-metabolism-vascular" axis. METS-VF may aid CVD risk stratification in CKM syndrome populations, and targeting insulin sensitivity may mitigate CVD risk.
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Zhang et al. (2026) conducted a cohort in Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0-3 (n=3,815). Elevated Metabolic Score for Visceral Fat (METS-VF) vs. Lowest quartile of METS-VF (Q1) was evaluated on Incident cardiovascular disease (CVD) (HR 1.615, 95% CI 1.243-2.097, p=<0.001). Elevated baseline Metabolic Score for Visceral Fat was associated with a 61.5% increased risk of incident cardiovascular disease (HR 1.615) compared to the lowest quartile.
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