Metabolic score for visceral fat profiles and incident cardiovascular disease in adults with CKM syndrome stages 0–3: a CHARLS longitudinal study

Key Points

• This research examines the connection between metabolic scores for visceral fat (METS-VF) and cardiovascular disease (CVD) in adults with CKM syndrome.
• Analyzed data from a longitudinal study using CHARLS database.
• Assessed METS-VF profiles in adults with CKM syndrome stages 0-3.
• Evaluated insulin sensitivity's role through eGDR to mediate the relationship between METS-VF and CVD.
• METS-VF profiles were found to significantly correlate with the incidence of CVD in CKM syndrome.
• The association was stronger in the later stages of CKM syndrome.
• Insulin sensitivity, as measured by eGDR, mediated the relationship between visceral fat and CVD.