What question did this study set out to answer?

To determine the best sampling protocols and specimen types for culturing bacteria in periprosthetic joint infections.

January 20, 2026Open Access

Optimization of sampling protocol, specimen types, and sampling sites in periprosthetic joint infections: a retrospective study

CCChenghan ChuSun Yat-sen University XWXiaoyu WuSun Yat-sen University ZWZilong WangSun Yat-sen University

Key Points

To determine the best sampling protocols and specimen types for culturing bacteria in periprosthetic joint infections.
Retrospective analysis of samples from patients with periprosthetic joint infections.
Assessment of culture yields based on different specimen types and anatomical sites.
Evaluation of contamination rates associated with various sampling methods.
MSP improved culture yields without raising contamination rates.
Optimal specimen types identified are synovial fluid, interface membrane, and pseudocapsule.
Femoral neck is the best site for hip infections, and intercondylar area for knee infections.

Abstract

The MSP enhanced the yield of cultures without increasing the contamination rate. The optimal specimen types for culture included synovial fluid, interface membrane, and pseudocapsule. For hip, the optimal anatomical site for culture was femoral neck. For knee, the optimal anatomical site for culture was intercondylar area.

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Cite This Study

Chu et al. (Sat,) studied this question.

synapsesocial.com/papers/696f1a849e64f732b51eed39 https://doi.org/https://doi.org/10.1186/s13018-026-06667-w

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