Comparison of the Friedewald, Sampson, and Martin Formulas with Direct Homogeneous Assay of Low-Density Lipoprotein Cholesterol in South American Patients.

Key Points

• This research compares different formulas for estimating low-density lipoprotein cholesterol against a direct assay reference.
• Analyzed S-LDL-c, M-LDL-c, and ME-LDL-c against D-LDL-c calculations.
• Conducted LRP analysis to assess accuracy in hypertriglyceridemia cases.
• Evaluated clinical implications of adopting newer LDL equations.
• S-LDL-c and M-LDL-c showed better alignment with D-LDL-c compared to F-LDL-c.
• S-LDL-c provided the most accurate estimations, particularly in patients with high triglycerides.
• Findings support replacing traditional formulas with newer alternatives in clinical practice.