Exercise duration was significantly associated with an increase in V̇O2 peak (0.42 mL/kg/min per hour/week; 95% CI 0.17-0.66; p=0.001) in patients with CHD and T2DM, whereas intensity was not.
Observational (n=201)
Does exercise duration and intensity improve peak oxygen uptake in older patients with coronary heart disease and type 2 diabetes?
In older patients with CHD and T2DM, exercise duration and frequency, rather than intensity, are the primary drivers of improvements in peak oxygen uptake during a 6-month home-based intervention.
Mean Difference: 0.42 (95% CI 0.17–0.66)
p-value: p=0.001
ABSTRACT Exercise training is recommended in coronary heart disease (CHD) and type 2 diabetes (T2DM) patients alike; however, uncertainty remains on the influence of exercise intensity and duration in older patients with both entities. To address this, we performed a secondary analysis including 201 patients (67.9 ± 8.2 years; 84.1% men) from the LeIKD trial (NCT038359), which introduced 6 months of home‐based telemedicine‐supported exercise intervention in patients with CHD and T2DM. We assessed the relationships between exercise duration and intensity with change in peak oxygen uptake (V̇O 2 peak) (simple and multiple regression analyses, α = 0.05). V̇O 2 peak increased by 0.42 mL/kg/min per hour of endurance exercise/week (95% CI: 0.17–0.66, p = 0.001). Exercise intensity was not significantly associated with the change in V̇O 2 peak ( p = 0.10). In a subgroup of patients with high adherence (≥ 66.7% of prescribed total duration and meeting prescribed exercise duration in ≥ 50% of weeks of intervention), a 10% increase in exercise intensity (mean % heart rate reserve (HRR)) was associated with an increase in V̇O 2 peak of 0.26 mL/kg/min (95% CI: 0.00–0.52; p = 0.05). Longer training duration within the initial 2 weeks of intervention was significantly associated with high adherence over 6 months (increased likelihood per 10 min/week: OR of 1.09 95% CI: 1.05–1.14, p < 0.001). Therefore, exercise duration but not intensity influences changes in V̇O 2 peak during exercise intervention in a high‐risk population of older patients with CHD and T2DM. In patients with high adherence to exercise duration, higher exercise intensity led to an additional increase in V̇O 2 peak. Training duration within the first 2 weeks was an important predictor of long‐term adherence. Trial Registration: https://www.clinicaltrials.gov : Identifier: NCT038359
Gass et al. (Thu,) conducted a observational in Coronary heart disease and type 2 diabetes (n=201). Exercise duration and intensity was evaluated on Change in peak oxygen uptake (V̇O2 peak) (0.42 mL/kg/min per hour/week, 95% CI 0.17-0.66, p=0.001). Exercise duration was significantly associated with an increase in V̇O2 peak (0.42 mL/kg/min per hour/week; 95% CI 0.17-0.66; p=0.001) in patients with CHD and T2DM, whereas intensity was not.