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January 20, 2026Journal of NanobiotechnologyOpen Access

A dual-action core-shell microneedle system restores mitochondrial function and accelerates healing in diabetic wounds

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Authors

XLXinyu LiHFHaojie FuCYChenghao Yang

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Overview

Demonstrates accelerated healing in diabetic wounds, suggesting a novel therapeutic approach for improved outcomes.

Key Points

  • The aim is to investigate a dual-action microneedle system to improve healing processes in diabetic wounds by restoring mitochondrial function.
  • Utilized single-cell RNA sequencing to identify VDAC1 as a target in diabetic wounds.
  • Developed a microneedle system composed of a ROS-responsive shell and a GelMA core.
  • Conducted experiments on diabetic mice and a diabetic pig model to assess healing and inflammation.
  • Achieved > 95% wound closure by day 14 in diabetic mice.
  • Restored mitochondrial function and shifted macrophages to a pro-regenerative phenotype with an M2/M1 ratio improvement.
  • Confirmed suppression of inflammatory signaling and activation of pro-angiogenic pathways through transcriptomic analysis.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/696f1ac19e64f732b51ef0fchttps://doi.org/10.1186/s12951-026-04048-3
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