Prognostic value of diffusely increased FDG uptake in spleen and/ or bone marrow due to reticuloendothelial system activation in lymphoma patients

Key Points

• This research aims to assess the prognostic impact of FDG uptake in the spleen and bone marrow for patients with lymphoma.
• Analyzed FDG uptake patterns in spleen and bone marrow using PET/CT imaging.
• Examined the correlation between FDG uptake and systemic inflammation markers.
• Conducted a clinicopathological assessment of lymphoma cases to determine prognostic relevance.
• Diffuse splenic FDG uptake correlates strongly with systemic inflammation levels.
• SLR (systemic inflammatory response) was identified as an independent predictor of progression-free survival.
• Diffuse bone marrow uptake suggests involvement of non-neoplastic factors requiring detailed assessment.