What question did this study set out to answer?

The aim is to investigate the protective effects of recombinant Dep44 against lung infections caused by K64-CRKP.

January 20, 2026Open Access

Protective effects of recombinant depolymerase Dep44 against K64-CRKP-induced pulmonary infection in a murine infection model

TYTao YanAnhui Medical University QLQi LiBGI Group (China)XTX TengAnhui Medical University

Key Points

The aim is to investigate the protective effects of recombinant Dep44 against lung infections caused by K64-CRKP.
Utilized a murine infection model to study the effects of Dep44.
Assessed the capsule-depolymerizing activity of Dep44.
Evaluated the impact on pulmonary infection severity.
Dep44 demonstrated significant protective effects against K64-CRKP lung infections.
The treatment conferred robust capsule-depolymerization, aiding in infection control.
Findings suggest Dep44 as a potential alternative to conventional antibiotic therapies.

Abstract

Dep44 exhibits robust capsule-depolymerizing activity and confers significant protection against K64-CRKP-induced lung infection in mice. These findings highlight its potential as a promising adjunct or alternative to antibiotic therapy for CRKP infections.

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