July 1, 2015Circulation Cardiovascular Imaging
Clinical Profile of Athletes With Hypertrophic Cardiomyopathy
Key result
Athletes with HCM display less LVH and larger cavities than sedentary HCM patients.
- P < 0.001
Why the study?
Does athletic status alter the electrical, structural, and functional cardiac phenotype in young patients with hypertrophic cardiomyopathy compared to sedentary patients?
Population
106 young (14–35 years) athletes with hypertrophic cardiomyopathy (HCM).
Comparison
Athletic status (regular exercise). vs 101 sedentary patients with HCM, and a secondary…
Design
Cross-sectional
Authors
Discussion
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Implication
May complicate echocardiographic differentiation of HCM from athlete's heart; leaves open need for prospective validation of refined criteria.
Structured PICO
Does athletic status alter the electrical, structural, and functional cardiac phenotype in young patients with hypertrophic cardiomyopathy compared to sedentary patients?
P
Population
106 young (14–35 years) athletes with hypertrophic cardiomyopathy (HCM).
I
Intervention
Athletic status (regular exercise).
C
Comparator
101 sedentary patients with HCM, and a secondary comparison group of 55 healthy athletes with mild physiological left ventricular hypertrophy (LVH).
O
Outcome
Electrical, structural, and functional cardiac parameters (including left ventricular hypertrophy, left ventricular cavity dimensions, and diastolic function).surrogate
Young athletes with HCM exhibit a distinct, milder structural and functional phenotype compared to sedentary HCM patients, making conventional echocardiographic differentiation from physiological LVH challenging in a subset of patients.
Cite This Study
Sheikh et al. (2015) studied this question. Athletes with hypertrophic cardiomyopathy displayed less left ventricular hypertrophy (15.8±3.4 mm) and larger cavities than sedentary HCM patients (P < 0.001).