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The aim is to isolate and characterize bioactive metabolites from the fungus Pleurocordyceps ophiocordycipiticola and evaluate their activities.

January 21, 2026RSC Advances0 citationsOpen Access

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Bioactive metabolites from cultures of the entomopathogenic fungus Pleurocordyceps ophiocordycipiticola TBRC-BCC 9612

SSSiriporn SaepuaNational Science and Technology Development Agency KSKaroon SadornKing Mongkut's Institute of Technology Ladkrabang JKJittra KornsakulkarnNational Science and Technology Development Agency

Key Points

The aim is to isolate and characterize bioactive metabolites from the fungus Pleurocordyceps ophiocordycipiticola and evaluate their activities.
Isolated metabolites from fungal cultures
Performed structural elucidation
Conducted bioassays to test antimicrobial and cytotoxic activities
Seven new metabolites were identified
Ergot alkaloids and tetramic acid derivatives exhibited antimalarial properties
Compounds demonstrated antibacterial, antifungal, and cytotoxic activities

Abstract

Seven new metabolites were isolated from Pleurocordyceps ophiocordycipiticola . Structural elucidation and bioassays revealed ergot alkaloids and tetramic acid derivatives with antimalarial, antibacterial, antifungal, and cytotoxic activities.

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Bioactive metabolites from cultures of the entomopathogenic fungus Pleurocordyceps ophiocordycipiticola TBRC-BCC 9612

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Abstract

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