Elevated plasma FABP4 concentration was a significant predictor of local postoperative complications within 90 days following total knee or hip arthroplasty (OR 1.521; 95% CI 1.190-1.944; P=0.001).
Cohort (n=500)
Do elevated circulating FABP4 levels predict local postoperative complications within 90 days in osteoarthritis patients undergoing joint arthroplasty?
Elevated circulating FABP4 levels are significantly associated with an increased risk of local postoperative complications within 90 days after joint arthroplasty.
Odds Ratio: 1.521 (95% CI 1.19–1.944)
p-value: p=.001
This study aimed to investigate the potential role of fatty acid binding protein 4 (FABP4) in predicting prognosis after total hip arthroplasty (THA) or total knee arthroplasty (TKA). A total of 400 patients undergoing TKA or THA and 100 healthy controls were included. Patients were categorized into a complication group if local postoperative complications occurred within 90 days post-surgery; otherwise, they were classified as the no complications group. The demographic and clinical data of the 2 groups were compared, and the clinical characteristics and risk factors of local postoperative complications within 90 days of TKA/THA were evaluated. Plasma FABP4 concentrations were measured using an ELISA kit. FABP4 concentration (odds ratio OR = 1.521, 95% confidence interval CI = 1.190–1.944, P = .001), American Society of Anesthesiologists physical status classification (OR = 0.064, 95% CI = 0.005–0.811, P = .034), and estimated intraoperative blood loss (OR = 1.070, 95% CI = 1.008–1.135, P = .027) were identified as significant predictors of 90-day local postoperative complications. Elevated levels of FABP4 are frequently observed in patients experiencing local postoperative complications within 90 days following TKA/THA. FABP4 concentration, American Society of Anesthesiologists class, and estimated intraoperative blood loss are risk factors for the development of this complications, although further validation in advanced clinical trials is required.
Lin et al. (Fri,) conducted a cohort in Osteoarthritis (n=500). Elevated circulating FABP4 levels was evaluated on Local postoperative complications within 90 days post-surgery (OR 1.521, 95% CI 1.190-1.944, p=.001). Elevated plasma FABP4 concentration was a significant predictor of local postoperative complications within 90 days following total knee or hip arthroplasty (OR 1.521; 95% CI 1.190-1.944; P=0.001).