The analysis showed an overall accuracy of ~80% for both iFR and Pd/Pa compared to FFR, with potential improvement to ≥90% in a subset of lesions.
Does the instantaneous wave-free ratio (iFR) and resting Pd/Pa provide comparable accuracy to fractional flow reserve (FFR) in assessing coronary lesions?
Nonhyperemic indices iFR and resting Pd/Pa demonstrate approximately 80% accuracy compared to FFR, indicating they may be useful alternatives to hyperemic assessment in selected patients.
This comprehensive core laboratory analysis comparing iFR and Pd/Pa with FFR demonstrated an overall accuracy of ~80% for both nonhyperemic indices, which can be improved to ≥90% in a subset of lesions. Clinical outcome studies are required to determine whether the use of iFR or Pd/Pa might obviate the need for hyperemia in selected patients.
Jeremias et al. (2013) studied this question. The analysis showed an overall accuracy of ~80% for both iFR and Pd/Pa compared to FFR, with potential improvement to ≥90% in a subset of lesions.