What question did this study set out to answer?

The aim is to evaluate the effect of Gum Arabica on plasma biomarkers related to inflammation and repair in chronic kidney disease.

January 22, 2026Open Access

Functional Molecular Plasma Biomarkers of Inflammation and Repair in Kidney Disease Progression in Gum Arabica Modality of CKD

Key Points

The aim is to evaluate the effect of Gum Arabica on plasma biomarkers related to inflammation and repair in chronic kidney disease.
Utilized colorimetric ELISA to measure biomarkers in plasma.
Conducted a prospective cohort study comparing Gum Arabica consumers with matched controls.
Collected data on health metrics such as hypertension, dyslipidemia, and diabetes prevalence.
Measured various biomarkers, including eGFR and sCr, in both groups.
Gum Arabica consumers showed significantly lower levels of leucine-rich alpha 2-glycoprotein and sirtuin 1 compared to controls.
Higher concentrations of lipocalin 2 and uromodulin were found in consumers than in controls.
No substantial differences in cystatin C, myeloperoxidase, orosomucoid 1, and symmetric dimethylarginine between groups.
Identified correlations between CKD duration and specific biomarkers in GA-consumers.

Abstract

Using colorimetric ELISA, this study aims to assess the impact of Gum Arabica (GA) consumption on functional molecular plasma biomarkers of chronic kidney disease (CKD) via a prospective cohort of GA-consumers (cases) vs. non-consumer (age- and CKD stage-matched) controls. Cohort’s hypertension (92.5%), dyslipidemia (64.8%), and diabetes mellitus (54.8%) were prevalent; the mean CKD duration was 6.94 years (SD 7.8) for both study groups. Comparable eGFR, sCr, ESR, CRP, HbA1c, FPG, UA, and fasting lipid parameters were in both study arms. In consumer cases, the mean duration of GA-consumption was 1.3 ± 1.1 (range 0.25–6) years with a mean dose of 1.7 ± 1.0 (range 0.5–6) spoons per day. Leucine-rich alpha 2-glycoprotein, plasminogen activator inhibitor 1, sirtuin 1, and SOST–sclerostin 1 were significantly (p value 0.05). Proportional correlations of CKD duration–PAI1 levels and sCr-lipocalin 2 levels but inverse correlations of orosomucoid 1-hypertension duration and SDMA-DBP were evident in cases.

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Cite This Study

Alshelleh et al. (Mon,) studied this question.

synapsesocial.com/papers/6971bd6a642b1836717e20bf https://doi.org/https://doi.org/10.3390/ijms27020973

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