Rhodomyrtus tomentosa fruit alleviates hippocampal neuroinflammation, apoptosis, and rescues neurogenesis to ameliorate depressive-like behaviors in CUMS-challenged mice

Key Points

• Evaluate the antidepressant effects of Rhodomyrtus tomentosa fruit on neuroinflammation and neurogenesis.
• Used CUMS (chronic unpredictable mild stress) model in mice
• Administered Rhodomyrtus tomentosa fruit extracts
• Assessed neuroinflammation and apoptosis in the hippocampus
• Rhodomyrtus tomentosa fruit reduced markers of neuroinflammation
• Increased neurogenesis in the hippocampus
• Ameliorated depressive-like behaviors in challenged mice