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Acidic In Vitro Selection of Metal-Specific Deoxyribozymes | Synapse

January 22, 2026Chemical Science0 citationsOpen Access

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Acidic In Vitro Selection of Metal-Specific Deoxyribozymes

PJPan JiaDalian University of Technology YCYangyang ChangDalian University of Technology SLShen LiDalian University of Technology

Key Points

This research aims to enhance metal selectivity in deoxyribozymes through novel selection techniques.
Conducted in vitro selection of deoxyribozymes
Focused on improving metal ion binding and specificity
Compared the performance of selected DNAzymes with conventional methods
Achieved improved selectivity for specific metal ions
Enhanced catalytic activity observed in selected deoxyribozymes
Demonstrated potential for practical applications in biochemistry and materials science

Abstract

Deoxyribozymes (DNAzymes) are in vitro selected catalytic DNA molecules that recruit metal ions to function. However, nearly all previous DNAzymes generated through conventional selection methods exhibit poor metal selectivity. Here...

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Cite This Study

Jia et al. (Thu,) studied this question.

synapsesocial.com/papers/6971bdcf642b1836717e2752 https://doi.org/https://doi.org/10.1039/d5sc08656f