Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis

Hao Huang; Zhiwei Guo; Xueping Yang; Linzi Qin

doi:10.1080/19585969.2026.2612918

January 20, 2026Dialogues in Clinical NeuroscienceOpen Access

Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis

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Key Points

This research aims to identify specific brain alterations associated with anxious depression and their potential as neurobiological markers.
Conducted a whole-brain fMRI analysis of subjects with anxious depression.
Performed a meta-analysis of existing literature to identify common brain alterations.
Evaluated the correlation between brain regional activity and depressive symptoms.
Identified distinct functional alterations in specific brain regions linked to anxious depression.
Found potential neurobiological markers that can differentiate aMDD from other mood disorders.

Implication

Meta-analysis reveals brain alterations as neurobiological markers for anxious depression, suggesting targeted interventions.

Abstract

We identified specific functional alterations in brain regions that may serve as potential neurobiological markers for aMDD and associated differences.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6971be8d642b1836717e32ad https://doi.org/10.1080/19585969.2026.2612918

View Full Paper

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Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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