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January 22, 2026Organic & Biomolecular Chemistry0 citations

A heteroatom of difference: investigation of thiazolidine- and oxazolidine-4-carboxylates as hydrolytically cleavable profragrances

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SLSerge LamboleyFirmenich (Switzerland)BVBasile VuichoudBABruno Simões de Almeida

Key Points

  • The research aims to explore heterocyclic profragrances for controlled release of fragrances in laundry care.
  • Synthesis of thiazolidine and oxazolidine carboxylates from amino acids
  • Testing fragrance release through hydrolysis under acidic and alkaline conditions
  • Comparative analysis of fragrance delivery efficiency during hydrolysis
  • Profragrances showed effective release of aldehydes and ketones
  • Hydrolysis rates varied significantly between acidic and alkaline environments
  • Thiazolidine derivatives demonstrated superior performance in fragrance stability

Abstract

Readily accessible amino-acid-derived 1,3-heterocyclic profragrances were evaluated to deliver perfumery aldehydes or ketones in laundry care applications by slow hydrolysis under acidic and alkaline conditions.

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Cite This Study

Lamboley et al. (2026) studied this question.

synapsesocial.com/papers/6971bfdff17b5dc6da021ed0https://doi.org/10.1039/d5ob01780g
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