What question did this study set out to answer?

This research aims to evaluate the clinical characteristics and treatment responses of moderately severe acute ulcerative colitis patients who do not meet Truelove and Witts criteria for acute severe ulcerative colitis.

January 23, 2026Journal of Crohn s and Colitis

P0276As severe as Acute Severe Ulcerative Colitis (ASUC)? Clinical findings from a large cohort of moderately severe acute Ulcerative Colitis inpatients

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This research aims to evaluate the clinical characteristics and treatment responses of moderately severe acute ulcerative colitis patients who do not meet Truelove and Witts criteria for acute severe ulcerative colitis.
Retrospective cohort study at a single tertiary referral center.
Inpatients diagnosed with moderately severe acute ulcerative colitis were analyzed based on stool frequency and treatment received.
Propensity score matching was performed to compare outcomes between moderately severe and acute severe ulcerative colitis patients.
Out of 563 admitted patients, 145 did not meet TWC for acute severe ulcerative colitis criteria.
40% response rate to intravenous corticosteroids in the moderately severe cohort.
Thirteen colectomies occurred in the moderately severe cohort, primarily in those with higher stool frequency.
Short-to-medium term colectomy risk was not significantly different between groups after matching for disease characteristics.

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Implication

Observational study characterizes disease severity and treatment responses in moderately severe acute ulcerative colitis inpatients, suggesting implications for clinical outcomes.

Cite This Study

Etchegaray et al. (2026) studied this question.

synapsesocial.com/papers/69730eabc8125b09b0d1e851 https://doi.org/10.1093/ecco-jcc/jjaf231.457

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Implication

Observational study characterizes disease severity and treatment responses in moderately severe acute ulcerative colitis inpatients, suggesting implications for clinical outcomes.

P0276As severe as Acute Severe Ulcerative Colitis (ASUC)? Clinical findings from a large cohort of moderately severe acute Ulcerative Colitis inpatients

Key Points

Discussion

Implication

Cite This Study

P0276As severe as Acute Severe Ulcerative Colitis (ASUC)? Clinical findings from a large cohort of moderately severe acute Ulcerative Colitis inpatients

Key Points

Discussion

Implication

Cite This Study

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