What question did this study set out to answer?

To investigate the relationship between visceral adiposity and metabolic profiles in inflammatory bowel disease (IBD) based on body mass index (BMI).

January 23, 2026Journal of Crohn s and Colitis

P0642Discordance between BMI and visceral adiposity identifies distinct inflammatory phenotypes in inflammatory bowel diseases

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To investigate the relationship between visceral adiposity and metabolic profiles in inflammatory bowel disease (IBD) based on body mass index (BMI).
Adult IBD patients were categorized by BMI and visceral adipose tissue (VAT) thickness using intestinal ultrasound (IUS).
Four VAT-BMI phenotypes were established: lean, visceral-predominant, peripheral, and combined.
Disease activity and metabolic comorbidities were assessed and compared across the identified phenotypes.
Statistical analyses included one-way ANOVA and the Freeman-Halton test.
The phenotype distribution among participants was 34% lean, 17% peripheral, 13% visceral-predominant, and 36% combined.
Significant differences in composite disease activity were observed, with lean phenotype showing the highest activity at 1 month (71%) and 3 months (81%).
IUS activity was highest in lean and lowest in combined/visceral-predominant phenotypes (p=0.0004).
Total cholesterol levels were significantly higher in the combined phenotype (p=0.049).

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Implication

This analysis identifies distinct inflammatory phenotypes linked to visceral fat levels in inflammatory bowel disease, suggesting new diagnostic insights.

Cite This Study

Simkin et al. (2026) studied this question.

synapsesocial.com/papers/69730eabc8125b09b0d1e869 https://doi.org/10.1093/ecco-jcc/jjaf231.823

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Implication

This analysis identifies distinct inflammatory phenotypes linked to visceral fat levels in inflammatory bowel disease, suggesting new diagnostic insights.

P0642Discordance between BMI and visceral adiposity identifies distinct inflammatory phenotypes in inflammatory bowel diseases

Key Points

Discussion

Implication

Cite This Study

P0642Discordance between BMI and visceral adiposity identifies distinct inflammatory phenotypes in inflammatory bowel diseases

Key Points

Discussion

Implication

Cite This Study

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