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January 23, 20261 citations

Epigenetic Age Versus Chronologic Age in Adult Spinal Deformity Surgery: A Prospective Cohort Study.

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QSQuante SingletonHospital for Special SurgeryRBRohit BhanIllinois CollegeYZYu Shrike ZhangKunming University of Science and Technology

Key Points

  • This research aims to examine the relationship between epigenetic age and postoperative complications in spinal deformity surgery patients.
  • Conducted a prospective cohort study
  • Measured epigenetic age and chronologic age in adult spinal deformity patients
  • Analyzed postoperative complications in relation to age types
  • Postoperative complications were correlated with elevated epigenetic age compared to chronologic age
  • Epigenetic age showed potential as a biomarker for preoperative risk assessment

Abstract

Postoperative complications in ASD patients were associated with epigenetic alterations and elevated EA relative to CA. These findings suggest EA may be a novel biomarker for preoperative risk stratification in ASD surgery.

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Cite This Study

Singleton et al. (2026) studied this question.

synapsesocial.com/papers/69730eabc8125b09b0d1e90ahttps://doi.org/10.1097/brs.0000000000005632
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