Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction—associated steatohepatitis

Xun-xun Chen; Hui-Ting Shi; Lili Xiao; Huan Li; Bin-Bin Du; Zhen Huang; Dian-Hong Zhang; Leiming Wu; Lina Wu; Jie-Lei Zhang

doi:10.1186/s12964-026-02668-8

January 21, 2026Cell Communication and SignalingOpen Access

Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction—associated steatohepatitis

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Key Points

The research aims to explore TRIM21's role in regulating STAT1 and its impact on metabolic dysfunction associated with steatohepatitis.
Analysis of TRIM21's effects on STAT1 regulation
Examination of ubiquitination processes in metabolic dysfunction
Evaluation of TRIM21's impact on hepatic steatosis
TRIM21 suppresses STAT1 through ubiquitination
TRIM21's role as a negative regulator of metabolic dysfunction is confirmed
Potential therapeutic implications for targeting TRIM21 in steatohepatitis are highlighted

Implication

Identifies TRIM21 as a regulator of STAT1 in metabolic dysfunction, suggesting new therapeutic avenues for steatohepatitis.

Abstract

The ubiquitination of STAT1 in MASH is regulated by TRIM21 which is a key suppressor of MASH. TRIM21 acts as a negative regulator in hepatic steatosis and offers potential therapeutic opportunities for MASH.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69730f18c8125b09b0d1ef17 https://doi.org/10.1186/s12964-026-02668-8

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Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction—associated steatohepatitis

Key Points

Implication

Abstract

Discussion

Cite This Study

Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction—associated steatohepatitis

Key Points

Implication

Abstract

Discussion

Cite This Study

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