Depth-oriented organ-preserving salvage endoscopic strategy with argon plasma coagulation and photodynamic therapy for residual or recurrent esophageal squamous cell carcinoma after chemoradiotherapy.

Naomi K. Fukagawa; Yasuaki Furue; Chikatoshi Katada; Kosuke Okuwaki; Kusutaro Doi; Gen Kitahara; Takuya Wada; Akinori Watanabe; Kenji Ishido; Satoshi Tanabe; Chika Kusano

doi:10.1093/jjco/hyaf221

January 21, 2026

Depth-oriented organ-preserving salvage endoscopic strategy with argon plasma coagulation and photodynamic therapy for residual or recurrent esophageal squamous cell carcinoma after chemoradiotherapy.

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Key Points

The aim is to evaluate a tailored endoscopic strategy for treating residual or recurrent esophageal squamous cell carcinoma after chemoradiotherapy.
Utilized argon plasma coagulation (APC) for cases classified as ycT1a.
Employed photodynamic therapy (PDT) for cases categorized as ycT1b-T2.
Adapted treatment strategy based on tumor invasion depth.
Demonstrated feasibility and safety of the endoscopic strategy.
Effectively controlled local disease in residual or recurrent cases.
Facilitated organ preservation in selected patients.

Implication

A salvage endoscopic strategy optimizes organ preservation and control in esophageal cancer post-therapy, highlighting its effectiveness.

Abstract

A salvage endoscopic strategy applying APC for ycT1a and PDT for ycT1b-T2, with flexibility based on tumor depth, is feasible, safe, and effective. Tailoring treatment to invasion depth may optimize organ preservation and local control in residual or recurrent ESCC after CRT.

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Cite This Study

Fukagawa et al. (2026) studied this question.

synapsesocial.com/papers/69730f34c8125b09b0d1f094 https://doi.org/10.1093/jjco/hyaf221

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Depth-oriented organ-preserving salvage endoscopic strategy with argon plasma coagulation and photodynamic therapy for residual or recurrent esophageal squamous cell carcinoma after chemoradiotherapy.

Key Points

Implication

Abstract

Discussion

Cite This Study

Depth-oriented organ-preserving salvage endoscopic strategy with argon plasma coagulation and photodynamic therapy for residual or recurrent esophageal squamous cell carcinoma after chemoradiotherapy.

Key Points

Implication

Abstract

Discussion

Cite This Study

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