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To establish a molecular remission score that defines comprehensive disease control in ulcerative colitis by analyzing mucosal signatures.

DOP142Defining comprehensive disease control in ulcerative colitis through a molecular remission score derived from mucosal transcriptomic and microbial signatures

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To establish a molecular remission score that defines comprehensive disease control in ulcerative colitis by analyzing mucosal signatures.
Collected 211 colonic biopsies from 173 patients with UC
Conducted bulk mRNA sequencing and 16S rRNA analysis
Categorized remission using biochemical, clinical, histological, and endoscopic criteria
Used a random forest model to identify predictive molecular features for disease control
Identified a molecular gradient between patients achieving comprehensive disease control and those who did not
Found distinct molecular and microbial signatures related to inflammation levels
19 transcriptomic features predictive of comprehensive disease control with AUC of 0.856
None of the 31 patients meeting comprehensive disease control criteria were hospitalized or required surgery during follow-up

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Defines disease control in ulcerative colitis through molecular and microbial assessments, suggesting a new understanding of remission metrics.

Hinrichsen et al. (2026) studied this question.

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Defines disease control in ulcerative colitis through molecular and microbial assessments, suggesting a new understanding of remission metrics.