What question did this study set out to answer?

To determine if the neonatal metabolome can predict the development of inflammatory bowel disease later in life.

DOP045Maternal environment captured by the neonatal metabolome is not predictive of later Inflammatory Bowel Disease

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To determine if the neonatal metabolome can predict the development of inflammatory bowel disease later in life.
Profiled dried blood spots from 520 newborns who developed IBD and 520 matched controls.
Used untargeted metabolomics via high-resolution mass spectrometry to measure 1,350 metabolites.
Assessed gestational and perinatal effects with PERMANOVA and employed gradient boosting for prediction.
Gestational factors explained minimal variance in neonatal metabolome (0.7% to 0.25%).
Metabolite predictions showed no significant correlation with IBD onset (R² = 0.09%, AUC = 0.51).
Genetic risk scores showed better predictive ability for IBD development (AUC = 0.68 for CD, AUC = 0.66 for UC).

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Investigation finds no predictive link between neonatal metabolome and inflammatory bowel disease, suggesting later-life risk accumulation.

Fracchia et al. (2026) studied this question.

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Investigation finds no predictive link between neonatal metabolome and inflammatory bowel disease, suggesting later-life risk accumulation.