Key result
In type 2 diabetes, low systolic blood pressure is not associated with increased all-cause mortality risk compared to higher blood pressure targets.
Why the study?
Is low systolic blood pressure associated with an elevated risk of all-cause mortality or cardiovascular and renal outcomes compared with higher BP targets in patients with type 2 diabetes?
Is low systolic blood pressure associated with an elevated risk of all-cause mortality or cardiovascular and renal outcomes compared with higher BP targets in patients with type 2 diabetes?
Low systolic blood pressure is not associated with increased all-cause mortality in patients with type 2 diabetes, suggesting that previously reported J-curve associations were likely due to reverse causation and unmeasured confounding.
Answers are grounded in this paper and cite their sources.
Challenges J-curve concerns for low SBP in type 2 diabetes; hypothesis-generating for safer targets pending randomized trials.
In type 2 diabetes, BP is linearly or monotonically associated with most cardiovascular and renal outcomes. Low SBP does not appear to be associated with an elevated risk of all-cause mortality compared with higher BP targets, suggesting that previously reported associations are likely due to reverse causation and unmeasured confounding.
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Wang et al. (2026) studied this question. In type 2 diabetes, low systolic blood pressure is not associated with increased all-cause mortality risk compared to higher blood pressure targets.
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