Long-acting HIV pre-exposure prophylaxis integrated with community-based sexual and reproductive health services in South Africa (LAPIS): study protocol for a hybrid (1a) cluster randomised controlled phase 3B trial of effectiveness and implementation.

Key Points

The study aims to evaluate the effectiveness and implementation of long-acting HIV pre-exposure prophylaxis integrated with community-based sexual and reproductive health services.
Conducting a hybrid (1a) cluster randomized controlled trial
Involving community-based sexual and reproductive health services
Focusing on effectiveness and implementation in South Africa
Expected to provide insights on the combined approach to HIV prevention
Aims to demonstrate improved access to reproductive health services
May reveal effectiveness in reducing HIV transmission rates

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Hybrid cluster randomized trial tests effectiveness of combined HIV prevention and health services, suggesting a new approach.

ClinicalTrials.gov Identifier-NCT06250504. Registered: 01 February 2024.

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Busang et al. (2026) studied this question.

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