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January 23, 2026Journal of Crohn s and Colitis

P0895Long-Term Efficacy of Upadacitinib in Patients With Moderate-to-Severe Crohn’s Disease and Prior Biologic Use

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Authors

RARaja AtreyaRPR PanaccioneELE Louis

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Overview

Post hoc analysis evaluates Upa's efficacy in Crohn’s disease, indicating sustained benefits despite prior therapy.

Key Points

  • To assess the long-term efficacy of upadacitinib in patients with moderate-to-severe Crohn’s disease who had prior inadequate responses to biologic therapy.
  • Post hoc analysis of patients from the U-ENDURE LTE study
  • Patients continued treatment with upadacitinib for an additional 96 weeks after 52 weeks of maintenance
  • Efficacy assessed through clinical and endoscopic endpoints like remission and response
  • ≥ 63.0% achieved sustained clinical remission per stool frequency/abdominal pain score
  • ≥ 59.1% achieved sustained endoscopic response
  • ≥ 71.0% maintained clinical remission per CDAI throughout the LTE
  • Efficacy rates were sustained or improved by week 96 compared to week 0 in both subgroups

Cite This Study

Atreya et al. (2026) studied this question.

synapsesocial.com/papers/69730f9fc8125b09b0d1f6f4https://doi.org/10.1093/ecco-jcc/jjaf231.1076
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