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January 23, 2026

P1199The epidemiological profil of patients with Inflammatory Bowel Disease

Key Points

This research aims to describe the epidemiological, clinical, and evolutionary characteristics of patients with inflammatory bowel disease.
Conducted a retrospective study involving 1800 patients with IBD.
Analyzed data collected over a 54-year period.
Examined the proportions of Crohn's disease and ulcerative colitis cases.
Investigated demographic factors such as age, sex ratio, and smoking prevalence.
67% of cases were Crohn's disease, with 33% ulcerative colitis.
The median diagnostic age was 32.5 years.
21.9% of IBD patients were chronic smokers, higher in Crohn's disease.
71% of patients were treated medically; 23.3% needed surgical intervention.

Abstract

Abstract Background In our country, the burden of Inflammatory Bowel Diseases (IBD); including Crohn’s Disease (CD) and Ulcerative Colitis (UC), is increasing. Yet local epidemiological data remain scarce, limiting understanding of their characteristics and management needs. Methods This retrospective study included 1800 patients who were followed for IBD in our center over 54 year period, with the aim of describing their epidemiological, clinical, and evolutionary characteristics. Results CD represented 67% of cases compared with 33% for UC, with a sexe ratio women / men of 1,3. The median diagnostic age was 32,5 25 ; 43 years. 63,4% of IBD cases were diagnosed within two years after the onset of symptoms. Among IBD patients, the overall prevalence of chronic smoking was 21,9%, higher in CD at 24,2% than in UC at 17,3%. 7,3% of patients had undergone an appendectomy, with a much higher proportion in CD (10,7%) compared to UC (0,3%). In CD, ileocolonic involvement and non-stricturing non-penetrating phenotype were the most frequent at 38,1% and 56,9% respectively. Anoperineal manifestations (APMs) were present in 28,8%. Left-sided colitis was predominent in UC (42.2%). Extraintestinal manifestations affected 30% of patients, mainly musculoskeletal (23,9%). Renal involvement was rare, with renal amyloidosis reported in 0,3% of cases, exclusively among CD patients. Overall, 71% were treated medically, whereas 23,3% required combined medical and surgical management. Major complications included bowel obstruction (3,3%), acute severe colitis (3,2%), malignant transformation (0,6%) and a mortality rate of 1,6%. Among cancer observed that were not related to IBD each case accounted for 0,1% of the study population, including acral lentiginous melanoma under thiopurine, two breast cancers (one under infliximab, one unrelated to treatment), cholangiocarcinoma under adalimumab, basal cell carcinoma unrelated to treatment, and esophageal cancer complicating Barrett’s esophagus. Conclusion These findings highlight the increasing burden of IBD and reveal clinical and evolutionary patterns comparable to international data, while reflecting specific features related to local epidemiological and healthcare contexts. Conflict of interest: Dr. Sabbah, Selma: No conflict of interest Lagdali, Nawal: No conflict of interest Kadiri, Maryeme: No conflict of interest Chabib, Fatima-Zahra: No conflict of interest Borahma, Mohamed: No conflict of interest Ajana, Fatima Zohra: No conflict of interest

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